Posted on August 30, 2020 by . View the profiles of professionals named "Jennifer Higham" on LinkedIn. This site is intended for US residents only. The neutrophil protein CD177 is a novel PDPN receptor that regulates human cancerassociated fibroblast physiology, Antibody toolkit reveals N-terminally ubiquitinated substrates of UBE2W, An Integrated Genomic, Proteomic, and Immunopeptidomic Approach to Discover Treatment-Induced Neoantigens, Discovery of a caspase cleavage motif antibody reveals insights into noncanonical inflammasome function, Machine-learning and chemicogenomics approach defines and predicts cross-talk of hippo and MAPK pathways, Activation of NF-B and p300/CBP potentiates cancer chemoimmunotherapy through induction of MHC-I antigen presentation, Proteomics in the pharmaceutical and biotechnology industry: a look to the next decade, Sensitive and quantitative detection of MHC-I displayed neoepitopes using a semiautomated workflow and TOMAHAQ mass spectrometry, Neutrophil serine protease 4 is required for mast cell-dependent vascular leakage, Integration of innate immune signalling by caspase-8 cleavage of N4BP1, The Immunoglobulin Superfamily Receptome Defines Cancer-Relevant Networks Associated with Clinical Outcome, Data on charge separation of bispecific and mispaired IgGs using native charge-variant mass spectrometry, Development of a therapeutic anti-HtrA1 antibody and the identification of DKK3 as a pharmacodynamic biomarker in geographic atrophy, Mutation position is an important determinant for predicting cancer neoantigens, Proteomic Analyses Identify a Novel Role for EZH2 in the Initiation of Cancer Cell Drug Tolerance, Characterization of bispecific and mispaired IgGs by native charge-variant mass spectrometry, Hippo Pathway in Cancer: Aberrant Regulation and Therapeutic Opportunities, The tumor suppressor BAP1 cooperates with BRAFV600E to promote tumor formation in cutaneous melanoma, Discovery and Qualification of Candidate Urinary Biomarkers of Disease Activity in Lupus Nephritis, A platform for extracellular interactome discovery identifies novel functional binding partners for the immune receptors B7-H3/CD276 and PVR/CD155, MAPPs for the identification of immunogenic hotspots of biotherapeutics; an overview of the technology and its application to the biopharmaceutical arena, Tumor suppressor BAP1 is essential for thymic development and proliferative responses of T lymphocytes, The kinase TPL2 activates ERK and p38 signaling to promote neutrophilic inflammation, De Novo MS/MS Sequencing of Native Human Antibodies, A Common Variant of IL-6R is Associated with Elevated IL-6 Pathway Activity in Alzheimer's Disease Brains, Building proteomic tool boxes to monitor MHC class I and class II peptides, Characterization of chain pairing variants of bispecific IgG Expressed in a single host cell by high-resolution native and denaturing mass spectrometry, RIPK1 inhibits ZBP1-driven necroptosis during development, Rapid, semi-automated protein terminal characterization using ISDetect, Response to comment on "sumo deconjugation is required for arsenic-triggered ubiquitylation of PML", Uncovering a dual regulatory role for caspases during endoplasmic reticulum stress-induced cell death, Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling, IgSimulator: A versatile immunosequencing simulator, Proteomic tools for the characterization of cell death mechanisms in drug discovery, Transcription factor ATF4 induces NLRP1 inflammasome expression during endoplasmic reticulum stress, Ig Repertoire Constructor: A novel algorithm for antibody repertoire construction and immunoproteogenomics analysis, SUMO deconjugation is required for arsenic-triggered ubiquitylation of PML, Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells, HSP105 recruits protein phosphatase 2A To dephosphorylate -catenin, Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing, Stable-isotope-labeled histone peptide library for histone post-translational modification and variant quantification by mass spectrometry, Evolutionary divergence in the catalytic activity of the CAM-1, ROR1 and ROR2 kinase domains, A turn-key approach for large-scale identification of complex posttranslational modifications, Combinatorial approach for large-scale identification of linked peptides from tandem mass spectrometry spectra, Toward understanding ubiquitin-modifying enzymes: From pharmacological targeting to proteomics, Peptide level immunoaffinity enrichment enhances ubiquitination site identification on individual proteins, Complementary methods for the identification of substrates of proteolysis, Endosomes are specialized platforms for bacterial sensing and NOD2 signalling, Phosphoproteomic analysis implicates the mTORC2-FoxO1 axis in VEGF signaling and feedback activation of receptor tyrosine kinases, Phosphorylation of dishevelled by protein kinase RIPK4 regulates Wnt signaling, The chromosome-centric human proteome project: A call to action, TRAF2 Sets a Threshold for Extrinsic Apoptosis by Tagging Caspase-8 with a Ubiquitin Shutoff Timer, Microwave-assisted protein staining, destaining, and in-gel/in-solution digestion of proteins, Loss of the tumor suppressor BAP1 causes myeloid transformation, Complementary proteomic tools for the dissection of apoptotic proteolysis events, Polyubiquitination of insulin-like growth factor I receptor (IGF-IR) activation loop promotes antibody-induced receptor internalization and down-regulation, Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling, Deubiquitinase USP37 Is Activated by CDK2 to Antagonize APCCDH1 and Promote S Phase Entry, Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7, Resurrection of a clinical antibody: Template proteogenomic de novo proteomic sequencing and reverse engineering of an anti-lymphotoxin- antibody, Comparative analysis of techniques to purify plasma membrane proteins, Template proteogenomics: Sequencing whole proteins using an imperfect database, Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival, Targeting interferon alpha subtypes in serum: A comparison of analytical approaches to the detection and quantitation of proteins in complex biological matrices, Cullin3-Based Polyubiquitination and p62-Dependent Aggregation of Caspase-8 Mediate Extrinsic Apoptosis Signaling, The double-histone-acetyltransferase complex ATAC is essential for mammalian development. This site is intended for US residents only. It is increasingly likely that the entirety of germline genetic variation impacting how our immune system responds to cancer accounts for some of the observed variability in responses to immune checkpoint blockade. Cook wanted to bring the GIO team together and give them a sense of shared purpose. If there are no women on a leaders list, the leader is expected to explain why to managers, HR business partners, executive coaches, and our organizational development team. Chatman's case tracks Genentech senior vice president and Haas alumna Jennifer Cook, MBA 98, who within a year transformed the culture of her Immunology and Ophthalmology (GIO) division after it was acquired by Swiss pharmaceutical giant Roche Group in 2009. To that end, attracting and retaining a diverse workforce and giving everyone the opportunity to advance to senior leadership positions is not just a moral and ethical imperative, its also a critical business priority. Jennifer Sandman* (N.Y. #3996634) PLANNED PARENTHOOD FEDERATION OF AMERICA 123 William Street, 9th Floor New York, NY 10038 (212) 261-4584 jennifer.sandman@ppfa.org Attorneys for Petitioners Planned Parenthood of Southwest and Central Florida; Planned Parenthood of South, East and North Florida; and Shelly Hsiao-Ying Tien, M.D., M.P.H. Ball; Marie Coignet; Shannon McCurdy; Spencer Knight; Raghavendran Partha; Brooke Rhead; Miao Zhang; Nathan Berkowitz; Michael Gaddis; Keith Noto; Luong Ruiz; Milos Pavlovic; Eurie L. 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