Details of the patients are summarized in Table 1. A score of 4 or 5 is an indicator to consider escalating therapy.25 Patients with Hodgkin lymphoma with a Deauville score of 1 or 2 have been shown to have similar progression and mortality outcomes between radiotherapy and no further treatment.32 Patients who receive a score of 3 or 4 should receive additional chemotherapy and/or radiotherapy, and a score of 5 indicates the need for a biopsy (excisional or core needle) in addition to chemotherapy and radiotherapy.25 A positive biopsy should be considered refractory disease.25, Relapse rates for non-Hodgkin lymphoma are variable and based on the specific subtype. Nucl. You are using a browser version with limited support for CSS. PET scan followed after a median uptake time of 68min (IQR, 63.576.5min). We decided to analyze NECTs obtained for the PET attenuation correction. Keywords:Deauville score, F-18 fluorodeoxyglucose positron emission tomography-computed tomography, Hodgkin's lymphoma. Provided by the Springer Nature SharedIt content-sharing initiative. The Spearman between Deauville score and SUV max approach was 0.31 (95% CI, 0.230.38). Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. ; Bernardo, M.P. The evaluation was carried out independently by two readers [Reader 1: S.N.N., Reader 2: L.J.J.] Post-therapy DS showed a sensitivity, specificity, PPV, NPV and accuracy of 66.7%, 97.8%, 95.7%, 80% and 94.2%, repsectively. 2023; 13(3):445. The site is secure. 86, 420428. PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma [J]. Faudemer, J. et al. [Initial treatment strategy for classical Hodgkin lymphoma in adults]. Context: Positron emission tomography (PET) using F-18 fluorodeoxyglucose (FDG) for treatment monitoring in patients with lymphoma is one of the most well-developed clinical applications. methods, instructions or products referred to in the content. A total of 128 patients with pathological grade 12 received multiple mild treatments and 91 patients with pathological grade 3a received rituximab-based systemic chemotherapy. Multiple requests from the same IP address are counted as one view. Med. J. Pers. Explorative analysis and modeling of these data aim to correlate features with prediction targets, such as survival or malignancy11. the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, All articles published by MDPI are made immediately available worldwide under an open access license. Brentuximab vedotin with chemotherapy for stage III or IV classical Hodgkin lymphoma (ECHELON-1): 5-year update of an international, open-label, randomised, phase 3 trial. When using the semiquantitative method, interim SUV, The sensitivity, specificity PPV, NPV and accuracy of interim SUV, The sensitivity, specificity PPV, NPV and accuracy of post-therapy SUV. Between March 2015 and October 2016, 170 patients were enrolled. Interobserver variability was calculated using weighted Kappa and presented with 95% confidence interval. For patients with high total metabolic tumor volume, the 2-year PFS rate was 90.9% (95% CI, 74.4 to 97.0) and 70.7% (95% CI, 39.4% to 87.9%) in the BV-AVD and ABVD arms, respectively. Hodgkin lymphoma in childhoodClinicopathological features and therapy outcome at 2 centres from a developing country. PMC ; Weller, E.; Backstrand, K.H. Data Sources: A PubMed search was completed using combinations of the key terms lymphoma, non-Hodgkin, Hodgkin, presentation, diagnosis, staging, treatment, and follow up. https://doi.org/10.1016/j.mri.2012.05.001 (2012). Careers. A risk model for relapsed/refractory aggressive NHL integrating clinical risk factors and pretransplant Deauville score. Reconstructed spatial resolution and contrast recovery with Bayesian penalized likelihood reconstruction (Q.Clear) for FDG-PET compared to time-of-flight (TOF) with point spread function (PSF). PubMed 2. Would you like email updates of new search results? ; Abdelkhalek, E.R. https://doi.org/10.1200/JCO.2013.53.5229 (2014). Rep. 6, 23428. https://doi.org/10.1038/srep23428 (2016). Cancer Res. Search dates: April 18, 2018, and August 30, 2019. In the meantime, to ensure continued support, we are displaying the site without styles J. Pers. CAS However, the prognostic value However, SUVmax did not predict the survival outcome using 59.8% of the optimal cutoff value. PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma [J]. Supplementary Tables S3 and S4 provide the full results of the MWU test (S3a,b) and ROC analysis (S4a,b) for scanners A and B. ROC curves of the three first-order features mean, median, and root mean squared(RMS), that concordantly distinguished Deauville score 4-positive and -negative lymphoma manifestations on both scanners. Slider with three articles shown per slide. Article The sensitivity, specificity, PPV, NPV and accuracy of interim DS in predicting a therapy response at 24 months were 80.4%, 100.0%, 100.0%, 40.0% and 82.7%, respectively. Barrington, S. F. et al. ; Cioni, D.; Neri, E. Are Semiquantitative Methods Superior to Deauville Scoring in the Monitoring Therapy Response for Pediatric Hodgkin Lymphoma? Frood, R. et al. J.Nucl. A DS of 3 or less is considered an adequate, and a DS of 4 or greater is considered an inadequate treatment response. and T.E. Search dates: April 18, May 17, and May 31, 2018, and August 30, 2019. Lymphoma typically presents as painless adenopathy, with systemic symptoms of fever, unexplained weight loss, and night sweats occurring in more advanced stages of the disease. Outcome-based interpretation of early interim PET in advanced-stage Hodgkin lymphoma. Blood. Radiomic features were extracted using PyRadiomics (Version 3.0)25,26, following the instructions of the Image Biomarker Standardisation Initiative (IBSI)27. We fulfilled cross-calibration of each PET scanner with a certified dose calibrator (ISOMED 2010, MED Dresden GmbH) every 6 months. Cancers (Basel). WebMy Research and Language Selection Sign into My Research Create My Research Account English; Help and support. Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. Patients should receive a 13-valent pneumococcal conjugate vaccine followed by a 23-valent pneumococcal polysaccharide vaccine at least eight weeks later with additional age-appropriate vaccinations because lymphoma is an immunosuppressive condition. A Feature High rMTV41% (rMTVhigh , 4.4 cm3 ) predicted significantly poorer EFS in patients with DS 4-5 (HR, 3.70; p = .014). Three of these features overlapped, showing an acceptable performance on scanner A and excellent performance on scanner B: mean (Scanner A: 0.75, B: 0.83), median (Scanner A: 0.75, B: 0.84), and RMS (Scanner A: 0.76, B: 0.83). Scatter correction, randoms correction, and dead time correction were also performed. ; writingoriginal draft preparation, L.J.J. 2013;54(11):2531-2533. ; validation, C.F.,H.A. PET/CT, however, is time Find support for a specific problem in the support section of our website. 2016;17(9):1283-1294. Cheson BD, Fisher RI, Barrington SF, Cavalli F, Schwartz LH, Zucca E. Biggi A, Gallamini A, Chauvie S, Hutchings M, Kostakoglu L, Gregianin M. Haioun C, Itti E, Rahmouni A, Brice P, Rain JD, Belhadj K. Hutchings M, Barrington SF. It is also an expensive and time-consuming procedure, resulting in a high radiation dose for the often young patients9. Please note that many of the page functionalities won't work as expected without javascript enabled. Phys. ; supervision, S.N.N. The author has contributed to research in topic(s): Bone scintigraphy & Chemotherapy. ADS Robin, X. et al. 8600 Rockville Pike Kinahan PE, Fletcher JW. The first-order feature median derived from NECT concordantly had a high sensitivity for DS4+ manifestations on both scanners, indicating cross-scanner applicability. van Griethuysen, J. J. M. et al. Med. Federal government websites often end in .gov or .mil. Ger, R. B. et al. Epub 2016 Jul 4. 18F-FDG-PET/CT is standard to assess response in Hodgkin lymphoma by quantifying metabolic activity with the Deauville score. Or Milgrom et al., who estimated the relapse rate of mediastinal Hodgkin Lymphoma by building a model with the five most predictive radiomic features from baseline PET scans, yielding promising AUCs13. ; Fisher, R.I.; Barrington, S.F. Unauthorized use of these marks is strictly prohibited. Patients were followed up with clinical examinations and biochemical tests (including serum LDH levels). Therefore, this study aimed to explore if radiomic features from NECT images are linked to the metabolic activity of Hodgkin lymphoma manifestations and can discriminate between DS4-negative (DS 13) and DS4-positive (DS4 and DS5) manifestations. Prognostic significance of baseline metabolic tumor volume in relapsed and refractory Hodgkin lymphoma. Brentuximab vedotin combined with ABVD or AVD for patients with newly diagnosed Hodgkin's lymphoma: a phase 1, open-label, dose-escalation study. Radiotherapy can also lead to long-term complications, including cardiac and pulmonary toxicity, hypothyroidism, or breast or lung cancers.2432 Radiotherapy can be avoided in patients with stage IA or IIA lymphoma without bulky disease25 (Table 319). The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Before Introduced to improve the consistency of PET interpretation3,4, the DS visually relates FDG uptake of a lymphoma manifestation to regions of physiological activity, i.e., the liver and the mediastinal blood pool5. ; methodology, S.N.N., J.M.M.R., I.G.S. Excluding the patients who had a Deauville score of 3, the 2-year PFS for PET-positive patients with a Deauville score of 4 to 5 was still excellent at 75%. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. Junita Rachel John1, Regi Oommen1, Julie Hephzibah1, David Mathew1, Anu Korula2, Nylla Shanthly1, Anu Eapen3
3D Slicer as an image computing platform for the Quantitative Imaging Network. Aide, N.; Lasnon, C.; Veit-Haibach, P.; Sera, T.; Sattler, B.; Boellaard, R. EANM/EARL harmonization strategies in PET quantification: From daily practice to multicentre oncological studies. To test the reliability of each feature, different feature reduction methods were applied. Management of classical Hodgkin lymphoma: a look at up to date evidence and current treatment approaches. 10 Results showed superior results for patients who were PET negative. Asthana, S.; Labani, S.; Mehrana, S.; Bakhshi, S. Incidence of childhood leukemia and lymphoma in India. Early interim FDG PET/CT prediction of treatment response and prognosis in pediatric Hodgkin disease-added value of low-dose CT. Kluge, R.; Kurch, L.; Georgi, T.; Metzger, M. Current role of FDG-PET in pediatric Hodgkins lymphoma. A bone marrow biopsy is now recommended only for diffuse large B-cell lymphoma with a negative PET-CT result.19. Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: The Lugano classification. ; project administration, S.P. Feature papers represent the most advanced research with significant potential for high impact in the field. Systemic symptoms of fever, unexplained weight loss, and night sweats occur in a subset of patients with more advanced disease. The results of all feature reduction methods are provided in the supplementary Tables S6a (Scanner A) and S6b (Scanner B). and JavaScript. (ac) A 20-year-old female patient with the initial diagnosis of Hodgkins lymphoma. doi: 10.1016/S2352-3026(21)00102-2. Rep. 10, 11649. https://doi.org/10.1038/s41598-020-68310-w (2020). Progression-free survival (PFS) was well stratified according to a visual assessment of interim PET/CT using 5-PS (p < 0.001). No special Reson. Results of a pivotal phase II study of brentuximab vedotin for patients with relapsed or refractory Hodgkin's lymphoma. Unable to load your collection due to an error, Unable to load your delegates due to an error. ; Amthauer, H.; Ruf, J.; Misch, D.; Schnberger, S.; Kobe, C.; Denecke, T.; Stver, B.; Hautzel, H.; et al. Comparison of commonly used SUV metrics for differentiation between paediatric tumours. Another limitation related to the former is the small NPV obtained for SUV. https://doi.org/10.1038/s41598-022-24227-0, DOI: https://doi.org/10.1038/s41598-022-24227-0. Deauville score versus ratio Deauville score in the interpretation of interim 18F-FDG PET-CT and in prediction of outcome in children with FDG-avid extra-nodal lymphomas. We aimed to compare the performance of Rheumatoid arthritis, systemic lupus erythematosus, Sjgren syndrome, dermatomyositis, and celiac disease are inflammatory conditions that increase the risk of lymphoma through disease-specific causes and the chronic use of immunosuppressive medications.8, Modifiable risk factors include current or former tobacco use9 and obesity (body mass index of 30 kg per m2 or higher).10 Breast implants and long-term pesticide exposure have also been associated with non-Hodgkin lymphoma.1113, Lymphoma commonly presents as painless adenopathy. Younes A, Gopal AK, Smith SE, et al. ; Hussein, M.H. Please enable it to take advantage of the complete set of features! https://CRAN.R-project.org/package=caret (2022). Mol. 2023 Standard of Care. Cite this article. Pretransplant Deauville score (DS) is an imaging biomarker used for risk stratification in relapsed/refractory classical Hodgkin lymphoma (cHL). Hodgkin lymphoma (HL) is one of the most common cancer types in young adults with the incidence peaking in people in their 20s. 58, 282287. Four patients were PET positive at the end of ABVD Ibrahim, F.; Gabelloni, M.; Faggioni, L.; Padma, S.; Visakh, A.R. J. Nucl. 77, e104e107. Oncol. This articledid not receive any funding. Le Roux PY, Gastinne T, Le Gouill S, Nowak E, Bodet-Milin C, Querellou S. Martelli M, Ceriani L, Zucca E, Zinzani PL, Ferreri AJ, Vitolo U. Barnes JA, LaCasce AS, Zukotynski K, Israel D, Feng Y, Neuberg D. Sedig LK, Bailey JJ, Wong KK, Brown RK, Kaminski MS, Hutchinson RJ. ; Kuyumcu, S.; Kebudi, R.; Sanli, Y.; Karakas, Z.; Cakir, F.B. R: A language and environment for statistical computing (R Foundation for Statistical Computing, Vienna, Austria, 2016). The primary endpoint was freedom from progression (FFP). WebThe blood level of lactate dehydrogenase (LDH), which goes up with the amount of lymphoma in the body Each poor prognostic factor is assigned 1 point. Barrington, S.F. PET data from scanner B were reconstructed iteratively with Bayesian penalized likelihood reconstruction (GE Q.Clear) with a penalization factor of 450, which included time of flight analysis and point spread function modeling21. Household contacts should receive appropriate CDC-recommended immunizations.43, This article updates a previous article on this topic by Glass.46. The authors declare no competing interests. Clipboard, Search History, and several other advanced features are temporarily unavailable. ; Amthauer, H.; Mller, H.W. They identified kurtosis associated with shorter progression-free survival of lymphoma patients, with analysis limited to first-order features14. ; Saleh, S.H. PET/CT mediastinal and liver FDG uptake: Effects of biological and procedural factors. Methods 188, 105111. Bethesda, MD 20894, Web Policies Rogasch, J. M. et al. Sci. We want to hear from you. PET data were acquired from the skull base to the proximal femora in 3D acquisition mode (acquisition time, 23min per bed position). Hussien, A.E. However, a clear tendency towards one texture feature or feature class that distinctly correlates with increased FDG uptake has not emerged yet. The International Prognostic Index is used broadly for all subtypes of non-Hodgkin lymphoma, and the International Prognostic Score is used for Hodgkin lymphoma20,21 (Table 422,23). You are accessing a machine-readable page. Indian J Nucl Med 2023;38:16-22: J. Nucl. Sci. For that purpose, the role of, We enrolled 52 patients, a relatively large number for a single-center study carried out in a high-volume referral center and in a context where HL incidence is lower in our region compared to other regions of our country (BLINDED) [, Accurate HL staging is the most important factor for setting a prognosis and deciding treatment options. BREACH is a multicenter, randomized, open-label, phase II trial. 32, 30483058. official website and that any information you provide is encrypted Meignan M, Gallamini A, Meignan M, Gallamini A, Haioun C. Report on the first international workshop on interim-PET-scan in lymphoma. Vandendriessche, D., Uribe, J., Bertin, H. & De Geeter, F. Performance characteristics of silicon photomultiplier based 15-cm AFOV TOF PET/CT. Shrout, P. E. & Fleiss, J. L. Intraclass correlations: Uses in assessing rater reliability. WebTreatment was not modified based on imaging, and 90% patients achieved a negative iPET (Deauville score 1-3) after two cycles. Routine vaccinations recommended by the Centers for Disease Control and Prevention (CDC) should resume, including any recommended inactivated or live vaccines three months after chemotherapy or six months after antiB-cell antibody therapy.43,45 Patients receiving a hematopoietic stem cell transplant should receive a series of three doses of Haemophilus influenzae type b vaccine starting six to 12 months after a successful transplant. CT-based texture analysis potentially provides prognostic information complementary to interim fdg-pet for patients with hodgkins and aggressive non-hodgkins lymphomas. Follows et al, British Journal of Haematology, 2014, 166, 3449. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate. Unauthorized use of these marks is strictly prohibited. permission is required to reuse all or part of the article published by MDPI, including figures and tables. A median activity of 250MBq 18F-FDG (interquartile range (IQR), 233262MBq) was administered intravenously. Eur. Copyright 2020 by the American Academy of Family Physicians. Sci. Ibrahim, A. et al. Korula A, Fouzia NA, Devasia A, Kulkarni U, Abraham A, Srivastava A. Bair SM, Svoboda J. Response-Adapted Treatment Strategies in Hodgkin Lymphoma Using PET Imaging. To achieve reproducible results, we determined the final DS using the qPET approach23. Fedorov, A. ; Klokman, W.J. Arai S, Fanale M, DeVos S, et al. PubMed Radiol. and B.H. The readers were required to delineate as much of the target lesion as possible while keeping a minimum distance of 12 pixels from the edge. Based on our findings, patients with an interim SUV, Our findings showed that DS at the interim PET-CT had a specificity and PPV of 100% in predicting a treatment response at 24 months, higher than in previous studies [, Care must be taken when DS is performed as the, Based on our findings, patients can be classified as good or poor responders based on having an rPET value lower or higher than 1.31, respectively, with a sensitivity of 76.1% and a specificity of 100%. 48, 7681. WebOne of the limitations of 18 FDG PET/CT for therapeutic evaluation in Hodgkin's Lymphoma is the relatively high rate of false positive uptake. also attempted to extract prognostic information from non-contrast-enhanced CT scans of patients with Hodgkins lymphoma and aggressive Non-Hodgkin lymphoma complementary to interim FDG-PET/CT. Eur. Adenopathy can wax and wane over years in indolent presentations or involve rapidly progressive adenopathy in more aggressive subtypes. Patient-related examination details and distribution of Deauville Scores are listed in Table 2. ; formal analysis, S.N.N., L.J.J., D.K., J.R, investigation, S.N.N., J.M.M.R., C.F., H.A. Analysis of MRI and CT-based radiomics features for personalized treatment in locally advanced rectal cancer and external validation of published radiomics models. WebA case report of synchronous primary gastric hodgkin lymphoma and lung adenocarcinoma and literature review Jew Win Kuan 1, Noraidah Masir 2 1 Department of Medicine, Faculty of Medicine and Health Sciences, Universiti Malaysia Sarawak, Kota Samarahan, Malaysia 2 Prince Court Medical Centre, Pantai Premier Pathology, Kuala Dose intensification with autologous bone-marrow transplantation in relapsed and resistant Hodgkin's disease: results of a BNLI randomised trial. Epub 2013 Nov 15. The conventional surgical procedure for lung adenocarcinoma is lobotomy with systematic mediastinal https://doi.org/10.1080/10428190903040048 (2009). Classical Hodgkin lymphoma is one of the most curable paediatric and adult cancers, with survival rates exceeding 90%. Med. Considering the dataset of scanner B, this accounted for 26 features. WebTailoring treatment in patients with Hodgkin lymphoma (HL) is paramount to maximize outcomes while avoiding unnecessary toxicity. Lancet Oncol. Google Scholar. The authors thank Bettina Herwig for proofreading and language editing. Article Ann Surg Oncol. and transmitted securely. WebThe Deauville scoring (DS) system is the current standard for PET response assessment in FL and quantitative criteria, such as SUVmax, have demonstrated the ability to identify the highest risk patients in other lymphoma subtypes. Bookshelf A metaanalysis of 18F-2-deoxy-2-fluoro-D-glucose positron emission tomography in the staging and restaging of patients with lymphoma. (reader 1: board-certified radiologist with over nine years of experience, reader 2: radiology resident with more than four years of experience). Disclaimer. All further statistical analyses were then performed scanner-wise: differences between DS4+ and DS4 manifestations were assessed with the MannWhitney-U-test and single feature performances with the ROC-analysis. interesting to readers, or important in the respective research area. All PET-CT parameters were strongly associated with the Deauville score (P<.001) and FFP (P<.0001) on univariate analysis. (This article belongs to the Special Issue, Tailoring treatment in patients with Hodgkin lymphoma (HL) is paramount to maximize outcomes while avoiding unnecessary toxicity. ; et al. SoftwareX 16, 100819. https://doi.org/10.1016/j.softx.2021.100819 (2022). The settings used for feature extraction can be found in the supplementary file S2a, the IBSI reporting guidelines and the checklist in the supplementary file S2b. Informed consent was obtained from all subjects involved in the study. 398 (John Wiley & Sons, 2013). R package version 4.71. Accessibility WebPeripheral T cell lymphoma (PTCL) is a rare subtype of non-Hodgkin lymphoma. We further determined the diagnostic performance of each feature to classify a lesion as DS4-positive or DS4-negative with the receiver operating characteristic (ROC) curve analysis using the pROC package29 (Version 1.18.0). Patients were classified as true positive at follow-up if they had evidence of disease at interim imaging, followed by persistent disease and/or evidence of recurrence at the end of therapy. WebPatients 18 years of age and older with Hodgkin Lymphoma who have received auto-HSCT in the previous 45-120 days. J. Nucl. The prognosis of patients with early-stage unfavorable Hodgkin lymphoma remains unsatisfactory. The .gov means its official. Ganeshan, B. et al. 2021 Jun;8(6):e410-e421. Oncol. Radiology 295, 328338. This site needs JavaScript to work properly. Patients with lymphoma should have intensive follow-up surveillance for the first two years following remission. Leuk Lymphoma 2009;50:1257-60. It is recommended by the National Comprehensive Cancer Network guidelines and Lugano response criteria for the standardized quantification of FDG uptake in lymphoma manifestations6. Berenguer, R. et al. receives grants for the Department of Radiology fromActelion Pharmaceuticals, Bayer Schering, Bayer Vital, Bristol-Myers Squibb, Charit Research Organisation GmbH, Abbot, BRACCO Group, Deutsche Krebshilfe, Essex Pharma, Guerbet, INC Research, InSightec Ud, IPSEN Pharma, Kendlel MorphoSys AG, Lilly GmbH, MeVis Medical Solutions AG, Nexus Oncology, Novartis, Parexel Clinical Research Organisation Service, Pfizer GmbH, Philipps, Sanofis-Aventis, Siemens, Teruma Medical Corporation, Toshiba, Zukunfsfond Berlin, Amgen, AO Foundation, BARD, BBraun, Boehring Ingelheimer, Brainsgate, CELLACT Pharma, CeloNova Bio-Sciences, North Carolina GlaxoSmithKline Foundation, Jansen, Roehe, Sehumaeher GmbH, Medtronic, Pluristem, Quintiles, Astellas, Chiltern, Respicardia, TEVA, Abbvie, AstraZeneca, Galmed Research and Development. PopUp = window.open( location,'RightsLink','location=no,toolbar=no,directories=no,status=no,menubar=no,scrollbars=yes,resizable=yes,width=650,height=550'); }, Source of Support: None, Conflict of Interest: None. Please enable it to take advantage of the complete set of features! Imaging in staging of malignant lymphoma: A systematic review. High total metabolic tumor volume was associated with a significantly shorter PFS (hazard ratio, 17.9; 95% CI, 2.2 to 145.5; P < .001). Support Center Find answers to questions about products, access, use, setup, and administration. Journal of Personalized Medicine 13, no. WebHodgkin Lymphoma and certain types of non-Hodgkin lymphomas. https://doi.org/10.1007/s11307-017-1155-x (2018). Annunziata, S.; Cuccaro, A.; Calcagni, M.L. An official website of the United States government. most exciting work published in the various research areas of the journal. Jerusalem G, Beguin Y, Fassotte MF, Najjar F, Paulus P, Rigo P. Cheson BD, Horning SJ, Coiffier B, Shipp MA, Fisher RI, Connors JM. AJR Am J Roentgenol 2019;212:456-60. Shahzadi, I. et al. ; Birch, J.M. ; Mauch, P.M. 2018 Jan 25;378(4):331-344. doi: 10.1056/NEJMoa1708984. A PET radiomics model to predict refractory Mediastinal Hodgkin lymphoma. Sign up for the Nature Briefing: Cancer newsletter what matters in cancer research, free to your inbox weekly. Lymphoma is a group of malignant neoplasms of lymphocytes with more than 90 subtypes. Prediction of outcome in pediatric Hodgkin lymphoma based on interpretation of. and D.K. government site. Corresponding Deauville criteria score 5. This study also demonstrated good interobserver agreement. Imaging Biol. Kobe, C. et al. Scientific Reports (Sci Rep) It is traditionally classified broadly as non-Hodgkin or Hodgkin lymphoma. ; Mostafa, H.M.; Elsayed, H.F.; Abo-ElAzm, O.M. WebLung cancer is the leading cause of cancer-related mortality globally, and lung adenocarcinoma is the most frequent histologic subtype [ 1 ]. Nucl. Younes A, Santoro A, Shipp M, et al. Gambhir, S.S. Molecular imaging of cancer with positron emission tomography. An open lymph node biopsy is preferred for diagnosis. Conceptualization, F.I. https://doi.org/10.1007/s00330-016-4470-8 (2017). The Deauville 5-point scoring system is an internationally accepted and utilized five-point scoring system for the Fluorodeoxyglucose (FDG) avidity of a Hodgkins lymphoma or Non-Hodgkins lymphoma tumor mass as seen on FDG Positron emission tomography. The extent and frequency of follow-up specifically depend on the histologic subtype of lymphoma. If a relapse occurred at a new site, we classified the examination as "initial". Positron emission tomography/computed tomography should be used to determine the staging of the lymphoma. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). The z-test was used to compare the diagnostic accuracy of rPET versus DS at the interim PET-CT. Of the 52 patients, 46 (88.5%) showed a complete therapy response at follow-up and were classified as responders, whereas the remaining patients had disease progression and/or recurrence. We included a total of 75 PET/CT datasets acquired in 43 patients. Harell, F. Jr. Hmisc: Harrell Miscellaneous. CT radiomics to predict Deauville score 4 positive and negative Hodgkin lymphoma manifestations. https://doi.org/10.3390/jpm13030445, Ibrahim, Firuz, Michela Gabelloni, Lorenzo Faggioni, Subramanyam Padma, Arun R. Visakh, Dania Cioni, and Emanuele Neri. Interestingly, even in NECT images, the feature median that ultimately describes the density of a lymphoma manifestation differentiated between DS4-positive and DS4-negative lesions, thereby showing constantly higher values in DS4-positive manifestations (numerical results of the radiomics analysis are provided in the supplementary Table S3; S3a for scanner A and S3b for scanner B).